Summary Laquinimod is a once daily, synthetic, oral immunomodulator currently under development for the treatment of relapsing-remitting multiple sclerosis (RRMS). Evidence of laquinimod’s efficacy in decreasing the rate of relapse in RRMS is inconsistent. Initial phase II and III placebo-controlled trials favoured laquinimod, but in a later pha...
Summary The autoRIC Device is a non-invasive device that provides automated delivery of remote ischemic conditioning (RIC), a temporary stop and restart of blood flow through a series of inflations and deflations of a blood pressure arm cuff. RIC is a novel adjunctive therapy for protection against ischemia-reperfusion injury in patients present...
Cite as: Otten N. Comparison of drug treatments for multiple sclerosis. Ottawa: Canadian Coordinating Office for Health Technology Assessment (CCOHTA); 1998. This rapid assessment brings together the major studies involving the four drugs available in various countries for the treatment of MS: Avonex® (interferon beta 1-a), Rebif® (interferon be...
Cite as: Noorani HZ. Coronary stents: clinical experience and cost-effectiveness. Ottawa: Canadian Coordinating Office for Health Technology Assessment (CCOHTA); 1997. Coronary stents are of value for the treatment of acute or threatened coronary artery closure complicating PTCA. Short-term clinical and angiographic outcomes are comparable with ...
Technology Computed Tomography (CT) and Magnetic Resonance Imaging (MRI). Disease This report explores 13 conditions for which the use of CT and MRI remain controversial: arteriovenous malformations carotid artery disease, cerebral aneurysms, coronary artery disease, headaches, head injuries, lung cancer screening, peripheral vascular disease, p...
Technology and Condition Continuous renal replacement therapy (CRRT) or intermittent hemodialysis (IHD) in critically ill adult patients with acute renal failure (ARF). There are 2,445 cases of ARF requiring dialysis among critically ill Canadian patients per year. Issues CRRT is a more costly therapy that has theoretical advantages over standar...